I would think you would want vsync anyway to prevent image tearing at such a high resolution. The moment you run a game at 40fps+ you won't notice any lag unless it drops below 30fps. Having a fps in the 100's does not make a game better. Most people who claim to have 100fps+ usually fluctuate all the way back down to around 50fps at times no matter how good their rigs are. I would just prefer to be at a consistent 50-60fps if I won't even notice the difference. Your video hardware would probably run with less of a payload anyway if you kept it from running all those excessive amounts of frames too...