Yes, do that!
Sorry, I meant route it down and behind your optical drive/HDD cage and then out along the HDD cage bottom.
It looks like you're pressed for space under the HDD cage so you might be forced to go with an 80mm fan. I prefer 120mm fans since they can move more air at a lower sound level, so if you could cut a gap into your HDD cage near the front of the case to allow a 120mm fan to fit, go for that route.
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